What is PreviDent 5000?
PreviDent 5000 Plus is a prescription-strength toothpaste containing 5000 ppm sodium fluoride, designed for enhanced dental caries protection and enamel remineralization.
Overview of PreviDent 5000 Plus
PreviDent 5000 Plus is a high-fluoride toothpaste formulated to actively combat dental caries, particularly root caries, and promote enamel remineralization. This prescription-only product delivers a concentrated 5000 ppm sodium fluoride, significantly exceeding the fluoride levels found in over-the-counter toothpastes.
Clinical studies demonstrate its effectiveness, showing substantial remineralization of root caries – up to 38% in under three months and 57% within six months. It’s designed for individuals at high risk of developing cavities, offering a powerful defense against tooth decay. The product is available in various formulations, including sensitive and ortho defense options, catering to specific patient needs.
PreviDent 5000 Plus can be applied with a standard toothbrush or utilized with custom-fitted trays for targeted fluoride delivery, as directed by a dental professional.
Key Ingredients and Their Purpose
The primary active ingredient in PreviDent 5000 Plus is 1.1% sodium fluoride (5000 ppm fluoride ion). This high concentration of fluoride strengthens tooth enamel, making it more resistant to acid attacks from bacteria and sugars, thus preventing cavities. Some formulations, like PreviDent 5000 Sensitive, also include 5% potassium nitrate.
Potassium nitrate is incorporated to help reduce tooth sensitivity by desensitizing the nerve endings within the teeth. This ingredient provides relief for individuals experiencing discomfort from sensitive teeth. The toothpaste base itself contains typical toothpaste components for cleaning and polishing, aiding in the removal of plaque and debris.
These combined ingredients work synergistically to offer both cavity protection and sensitivity relief, promoting overall oral health.

Prescription and Usage Guidelines
PreviDent 5000 requires a prescription due to its high fluoride content, and is intended for individuals at high risk of developing dental caries.
When is PreviDent 5000 Prescribed?
PreviDent 5000 is typically prescribed by dental professionals for patients exhibiting a high risk of developing tooth decay. This includes individuals with a history of frequent cavities,
existing root caries, dry mouth conditions (xerostomia), undergoing orthodontic treatment, or those who have experienced significant enamel erosion.
Patients with exposed root surfaces are particularly vulnerable to root caries, making PreviDent 5000 a valuable preventative measure. Furthermore, it’s often recommended post-radiation therapy for head and neck cancer, as radiation can reduce salivary flow and increase caries risk. Your dentist will assess your individual oral health needs and determine if this high-fluoride toothpaste is appropriate for you.
Dosage and Frequency of Use
Generally, adults and children over six years of age are instructed to use PreviDent 5000 twice daily, replacing their regular toothpaste. A pea-sized amount is sufficient for each brushing session. It’s crucial to avoid swallowing the toothpaste and to rinse thoroughly after brushing.

For patients utilizing custom trays, the dosage and wear time will be specifically determined by your dentist. Typically, the trays are filled with the gel and worn for a specified period, often several minutes, before bedtime. Consistent adherence to the prescribed dosage and frequency is vital for maximizing the therapeutic benefits of PreviDent 5000 and achieving optimal oral health.

Application Methods

PreviDent 5000 can be applied directly to a toothbrush or dispensed into custom-fitted trays provided by your dental professional for targeted treatment.
Using PreviDent 5000 with a Toothbrush
When utilizing PreviDent 5000 with a toothbrush, a pea-sized amount is generally sufficient to effectively coat all tooth surfaces. Brush thoroughly for two minutes, twice daily, or as directed by your dentist.
Ensure you cover all areas, including the front, back, and chewing surfaces of each tooth. Avoid swallowing the toothpaste; spit it out completely after brushing. PreviDent 5000 Sensitive, containing potassium nitrate, is easily applied this way.
Remember to use it in place of your regular toothpaste unless otherwise instructed. Consistent and proper brushing technique maximizes the benefits of this high-fluoride toothpaste, promoting enamel remineralization and caries protection.
Application with Custom Trays
For patients receiving custom trays with PreviDent 5000, a small amount of the fluoride gel should be placed into each tray, typically enough to cover the facial surfaces of the teeth. Carefully insert the trays into your mouth, ensuring a snug fit against your teeth.
Apply gentle pressure to allow the gel to contact all tooth surfaces. Leave the trays in place for the duration recommended by your dental professional – often several minutes. Avoid swallowing any excess gel; spit it out after removing the trays.
Rinse your mouth thoroughly with water after use. Custom trays facilitate direct application, maximizing fluoride contact and enhancing remineralization, particularly for those with specific dental needs.

Benefits of Using PreviDent 5000
PreviDent 5000 significantly remineralizes root caries, offering substantial protection against tooth decay and promoting overall oral health and enamel strength.
Remineralization of Tooth Enamel
PreviDent 5000’s high concentration of sodium fluoride actively promotes the remineralization of tooth enamel, a crucial process in preventing and reversing early signs of tooth decay. This prescription toothpaste delivers a potent dose of fluoride ions directly to the enamel surface, facilitating the deposition of calcium and phosphate.
Clinical studies demonstrate PreviDent 5000 Plus can significantly remineralize root caries – by 38% in under three months, and an impressive 57% within six months. This remineralization strengthens weakened enamel, making teeth more resistant to acid attacks from bacteria and dietary sugars. Consistent use, as directed by a dental professional, is key to maximizing these restorative benefits and maintaining optimal oral health.
Protection Against Root Caries
Root caries, or decay affecting the root surface of the teeth, pose a significant threat, particularly as gums recede with age. PreviDent 5000 offers targeted protection against this vulnerability due to its high fluoride concentration. The potent 5000 ppm sodium fluoride actively strengthens root surfaces, making them less susceptible to acid erosion and subsequent decay.
The clinically proven efficacy of PreviDent 5000 Plus demonstrates substantial remineralization of root caries, offering a proactive defense. By delivering a concentrated fluoride boost, it helps rebuild enamel and fortify the tooth structure. Consistent application, guided by a dental professional, is essential for maximizing protection and preserving long-term oral health, especially for individuals prone to root decay.

Specific Formulations
PreviDent 5000 is available in formulations like Sensitive, with potassium nitrate, and Ortho Defense, tailored for specific patient needs and conditions.
PreviDent 5000 Sensitive
PreviDent 5000 Sensitive is a specialized formulation designed for individuals experiencing tooth sensitivity. This toothpaste combines the high fluoride content of 5000 ppm sodium fluoride with 5% potassium nitrate, a well-known desensitizing agent. The potassium nitrate works by helping to block pain signals from the tooth’s nerve, providing relief from discomfort caused by hot, cold, sweet, or acidic stimuli.
Application is straightforward: use twice daily, brushing thoroughly after each use, just as you would with a regular toothpaste. It’s intended to replace your usual toothpaste unless otherwise directed by your dental professional. The squeeze bottle allows for easy application directly onto a toothbrush, ensuring consistent dosage and convenient use for those with sensitive teeth.
PreviDent 5000 Ortho Defense
PreviDent 5000 Ortho Defense is specifically formulated for patients undergoing orthodontic treatment with braces. Braces create numerous hard-to-reach areas where plaque and food debris can accumulate, increasing the risk of cavities and enamel demineralization. This toothpaste delivers a high concentration of 5000 ppm sodium fluoride to effectively combat these challenges.
For optimal results, use twice daily during orthodontic treatment, brushing thoroughly after each use. Pay close attention to cleaning around brackets and wires. Your orthodontist may also recommend using custom trays with PreviDent 5000 Ortho Defense for enhanced fluoride delivery. Consistent use, as directed by your dental professional, is crucial for maintaining oral health throughout your orthodontic journey.

Potential Side Effects and Precautions
While generally safe, PreviDent 5000 may cause mild irritation. Avoid swallowing and discontinue use if excessive irritation occurs; consult your dentist.
Common Side Effects

PreviDent 5000, being a high-fluoride toothpaste, can occasionally cause some mild and temporary side effects. The most frequently reported is a slight, transient irritation to the gums or oral mucosa. Some individuals may experience a temporary stinging sensation, particularly if there are existing abrasions or inflammation in the mouth.
Another common, though usually minor, side effect is a temporary alteration in taste perception. This is typically described as a metallic or unpleasant taste that resolves shortly after brushing. Rarely, some users might experience mild gastrointestinal upset if a small amount of toothpaste is inadvertently swallowed, though this is uncommon with proper usage.
These side effects are generally mild and subside quickly. However, it’s crucial to follow the prescribed dosage and usage guidelines to minimize their occurrence.
Important Safety Considerations
PreviDent 5000 is a prescription product and should only be used under the guidance of a dental professional; Due to its high fluoride content, it’s crucial to minimize swallowing. Keep out of reach of children, and supervise young children during brushing to ensure proper usage and prevent accidental ingestion.
Prolonged or excessive fluoride intake can lead to dental fluorosis (affecting tooth enamel development in children) or, rarely, skeletal fluorosis. Individuals with known allergies to fluoride should avoid using this product.
If you experience any severe or persistent adverse reactions, discontinue use and consult your dentist immediately. It’s important to inform your dentist about all other fluoride sources you are using, such as fluoridated water or supplements, to avoid excessive fluoride exposure.

Storage and Handling
PreviDent 5000 should be stored at room temperature, away from direct sunlight and moisture, ensuring the tube is tightly sealed after each use.
Proper Storage Conditions
To maintain the efficacy of PreviDent 5000, proper storage is crucial. Keep the toothpaste tube sealed tightly after each use to prevent exposure to air and potential contamination. Store it in a cool, dry place, avoiding areas with excessive humidity, like bathrooms directly exposed to shower steam.
Avoid storing the product in direct sunlight or near heat sources, as elevated temperatures can degrade the fluoride concentration and compromise its effectiveness. Room temperature is ideal – generally between 68°F and 77°F (20°C and 25°C). Ensure the product remains out of reach of children and pets to prevent accidental ingestion. Proper storage helps preserve the integrity and therapeutic benefits of PreviDent 5000.
Expiration Date and Disposal
Check the PreviDent 5000 tube for an expiration date, typically printed on the crimped end. Using expired toothpaste may reduce its effectiveness due to potential degradation of the fluoride content. Do not use the product if it has passed its expiration date; discard it responsibly.
When disposing of the empty tube, follow your local waste management guidelines. While a small amount of remaining toothpaste is generally considered safe for disposal in household trash, avoid flushing it down the drain. Consider rinsing the tube thoroughly before disposal to minimize waste. Always prioritize responsible disposal practices to protect the environment and ensure public safety.